COHERE - external researchers

COHERE is a joint initiative between Health Canada and the CNSC. Health Canada researcher bios are listed below.

Lindsay Beaton, PhD

Research Scientist, Consumer and Clinical Radiation Protection Bureau, Health Canada

Expertise

Radiation Biology, Radiation Protection, Biodosimetry, Imaging Flow Cytometry, Human Health Risk Assessment High-Throughput Methodologies for Biodosimetry

Preferred language

English or French

Roles and responsibilities

Lindsay Beaton is a research scientist at the Consumer and Clinical Radiation Protection Bureau (CCRPB) at Health Canada (HC). Her research focuses on the biological effects of ionizing radiation. More specifically, she has been studying biomarkers of radiation sensitivity, developing triage assays for large population exposures and examining the impact of radiation on astronauts during long-term space travel. She is CCRPB’s lead risk assessor, participating in the HC Task Force on Scientific Risk Assessment, leading the Information Sharing Mechanism working group and developing the risk assessment framework for radiation-emitting devices.

Lindsay is passionate about mentoring students and is a member of the Carleton University Alumni Mentoring Program. She is also a member of the CCRPB/RPB Diversity and Inclusivity Working Group.

Current research and/or projects

  • Developing, updating and validating biodosimetry methods on new or updated technologies
  • Developing Monte Carlo models of ionizing radiation-emitting devices (such as cabinet X-ray machines and medical imaging devices) to model biological samples to help improve biological dosimetry methods.
  • Building upon the internal capacity and framework for performing risk assessments on radiation-emitting devices to inform risk management

Education

  • BEng in Engineering Physics, Carleton University
  • MSc in Medical Physics (Radiobiology), Carleton University
  • PhD in Medical Physics (Radiobiology), Carleton University

Affiliations

  • Member of the Ottawa Medical Physics Institute (OMPI), serving as secretary on the OMPI Executive
  • Member of the Canadian Organization of Medical Physicists (COMP), serving on the COMP Imaging Sub-Committee
  • Member of the European Radiation Research Society (ERRS)
  • Member of the IABERD

Awards

  • Carleton University Co-op Employer of the Year Award (2020)
  • Consumer and Clinical Radiation Protection Bureau Certificate of Recognition for work on the Laser Safety and Injury Surveillance Team (2019)
  • Healthy Environments and Consumer Safety Branch Instant Award for contributions to the Information, Surveillance and Co-ordination Division Working Group (2018)

Key publications

Q. Wang, M.A. Rodrigues, S. Pampou, L.A. Beaton-Green, J. Perrier, G. Garty, D.J. Brenner, H.C. Turner, R.C. Wilkins. Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay. Radiation Research (2019).

M.A. Rodrigues, L.A. Beaton-Green, R.C. Wilkins, M.F. Fenech. The Potential for Complete Automated Scoring of the Cytokinesis Block Micronucleus Cytome Assay Using Imaging Flow Cytometry. Minireview for a Special Issue of Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 836 pp.53-64 (2018) DOI:10.1016/j.mrgentox.2018.05.003.

R.C. Wilkins, M.A. Rodrigues, L.A. Beaton-Green. The Application of Imaging Flow Cytometry to High-Throughput Biodosimetry. Genome Integrity, 8(1) pp.7 (2017).

L.A. Beaton-Green, M.A. Rodrigues, S. Lachapelle, R.C. Wilkins. Foundations of Identifying Individual Chromosomes by Imaging Flow Cytometry With Applications in Radiation Biodosimetry. Methods, 112 pp. 18-24 (January 2017) doi.org/10.1016/j.ymeth.2016.08.006.

Additional links

Vinita Chauhan, PhD

Expertise

Radiation Biology, Biochemistry, Genomics, Molecular Biology, Adverse Outcome Pathways

Debora Quayle, MSc

Division Chief, Radiation Protection Bureau, Health Canada

Expertise

Radiation Protection, Nuclear Emergency Preparedness and Response

Roles and responsibilities

Debora Quayle is a research manager with the Radiation Protection Bureau at Health Canada. Her team includes the National Radon Program, the National Internal Radiation Assessment Program and Canada’s National Dose Registry. She also oversees the development of federal recommendations for existing and emergency exposure situations in Canada, provides radiation health protection advice to address public concerns, and manages a small research program to support radiation risk assessment. Ms. Quayle is co-chair of Theme Area 1 of the Federal Nuclear Science and Technology Work Plan – Supporting the development of biological applications and understanding the implications of radiation on living things. She is a member of the COHERE Scientific Committee.

Awards

  • Health Canada, Healthy Environments and Consumer Safety Assistant Deputy Minister Award for Excellence, Leadership, as part of the Exercise Unified Response design team (2014)
  • Defence Research and Development Canada, Award for Leadership and Creative Management (2012)
  • Health Canada, Healthy Environments and Consumer Safety Assistant Deputy Minister Award for Excellence, Exemplary Contribution as part of the RPB Japan (Fukushima) Response Team (2011)
  • Health Canada Deputy Minister’s Award for Excellence, Leadership, V2010 Olympic deployment (2010)
  • Health Canada, Healthy Environments and Consumer Safety Assistant Deputy Minister Award for Excellence, Leadership, V2010 Olympic deployment (2010)

Key publications

  • Green, A.R; Erhardt, L; Lebel, L; Duke, M.J.M; Jones, T; White, D; and Quayle, D. Overview of the full-scale radiological dispersal device field trials. Health Physics. 110:5, 403-417. 2016.
  • Erhardt, L; Lebel, L; Korpach, E; Berg, R; Inrig, E; Watson, I; Liu, C; Gilhluly, C; Quayle, D. Deposition measurements from the full-scale radiological dispersal device field trials. Health Physics. 110:5. 442-457. 2016.
  • Quayle, D; Ungar, K; Hoffman, I; Korpach, E. Developments in Radiological-Nuclear Support to Security through the Canadian CBRNE Research and Technology Initiative. Proceedings of the Third European IRPA Congress 2010.

Dr. Baki Sadi, PhD

Research Scientist, Radiation Protection Bureau, Health Canada

Expertise

Radiochemistry, Internal Dosimetry, Cellular Toxicology

Preferred language

English

Roles and responsibilities

Dr. Sadi is a research scientist with the Radiation Protection Bureau at Health Canada. With COHERE, Dr. Sadi conducts research on dosimetry and cellular toxicity in order to better understand biological and health effects from internal contamination of radionuclides at the levels relevant to environmental exposure.

Current research and/or projects

A better understanding of radon dosimetry through indoor aerosol characterization and computational simulation Health effects of chronic exposure to natural uranium in drinking water

Development of an adverse outcome pathway (AOP) relevant to uranium-induced kidney toxicity

Education

PhD in Analytical Chemistry

Key publications

Raymond Ko, Chad Shew, Sharman Perera, Baki Sadi, Kristine Mattson, Kathy Nielsen, David Kelly, Ed Waller, Chunsheng Li, Investigation of Internal Radionuclide Contamination from the Analysis of Nasal Swabs and Facial Swipes, Journal of Radioanalytical and Nuclear Chemistry, 301(1): 147-152 (2014).

Baki B. Sadi, Allison Fontain, Daniel McAlister, and Chunsheng Li, An Emergency Radiobioassay Method for Determination of 90Sr and 226Ra in a Spot Urine Sample, Analytical Chemistry, 87(15):7931-7937 (2015).

Chunsheng Li, Paolo Battisti, Philippe Berard, Alain Cazoulat, Antonio Cuellar, Rodolfo Cruz-Suarez, Xiongxin Dai, Isabella Giardina, Derek Hammond, Carolina Hernandez, Stephen Kiser, Raymond Ko, Sheila Kramer-Tremblay, Yannick Lecompte, Eva Navarro, Cristina Navas, Baki Sadi, Inmaculada Sierra, Freddy Verrezen, Maria A Lopez. EURADOS Laboratory Intercomparison on Emergency Radiobioassay, Radiation Protection Dosimetry, 167(4):472-484 (2015).

Jing Chen, Weihua Zhang, Baki Sadi, A report of radioactivity measurements of freshwater fish samples from the national capital region of Canada. Journal of Environmental Radioactivity, 144:175-178 (2015).

Lauren Bergman, Jae Young Lee, Baki Sadi, Jing Chen, Radon exhalation from sub-slab aggregate used in home constructions in Canada. Radiation Protection Dosimetry, 164:606-611 (2015).

Yacoob Shaikh, Edward P.C. Lai, Baki Sadi, Chunsheng Li, Magnetic nanoparticles impregnated with 18-crown-6 ether: hybrid material synthesis for binding and detection of radioactive strontium, Nanoscience and Technology, 2(1):1-5 (2015).

Zack Varve, Edward Lai, Chunsheng Li, Baki Sadi, Selective extraction of Sr-90 in urine using 44(5)di-tertbutyl dicyclohexano-18-crown-6 ether polyacrylamide-coated magnetic nanoparticles, Journal of Radioanalytical and Nuclear Chemistry, 303(1): 1053-1057 (2015).

Li, C., Ansari, A., Bartizel, C., Battisti, P., Franck, D., Gerstmann, U., Giardina, I., Guichet, C., Hammond, D., Hartmann, M., Jone, R. L., Kim, E., Ko, R., Morhard, R., Quayle, D., Sadi, B., Saunders, D., Paquet, F. GHSI Emergency Radionuclide Bioassay Laboratory Network - Summary of a Recent Exercise, Radiation Protection Dosimetry, 171(3): 351-357 (2016).

Sadi, B. B., Chen, J., Kochermin, V., Tung, G., Chiorean, S. A faster sample preparation method for determination of polonium-210 in fish. Journal of Radioanalytical and Nuclear Chemistry, 308: 843-850 (2016).

Jing Chen, Michael D. Rennie, Baki Sadi, Weihua Zhang, and Nadereh St-Amant, A study on the levels of radioactivity in fish samples from the experimental lake area in Ontario, Canada, Journal of Environmental Radioactivity, 153: 222-230 (2016).

Sadi, B., Li, C., Ko, R., Daka, J., Yusuf, H., Wyatt, H., Surette, J., Priest, N., Hamada, N. A study on the effect of internal exposure to 210Po on the excretion of urinary proteins in rats. Radiation and Environ mental Biophysics, 55(2): 161-169 (2016).

Sadi, B., Lee, J. Y., Chen, J. A dispersive liquid-liquid microextraction technique for the determination of 210Pb in drinking water samples. Journal of Radioanalytical and Nuclear Chemistry, 310: 99-108 (2016).

Chen, J., Zhang, W., Sadi, B., Wang, X., Muir, D.C.G. Activity Concentration Measurement of Selected Seals from Canadian Arctic, Journal of Environmental Radioactivity, 169-170: 48-55 (2017).

Li, C., Bartizel, C., Battisti, P., Böttger, A., Bouvier, C., Capote-Cuellar, A., Carr, Z., Hammond, D., Hartmann, M., Heikkinen, T., Jones, R., Kim, E., Ko, R., Koga, R., Kukhta, B., Mitchell, L., Morhard, R., Paquet, F., Quayle, D., Rulik, P., Sadi, B., Sergei, A., Sierra, I., Sousa, W., Szabό, G. GHSI Emergency Radionuclide Bioassay Laboratory Network - Summary of the Second Exercise, Radiation Protection Dosimetry, 174(4): 449-456 (2017).

Sadi, B. B., Rinaldo, C., Spencer, N., Li, C. An Ion Chromatographic Separation Method for the Sequential Determination of 90Sr, 241Am and Pu isotopes in a urine sample, Journal of Radioanalytical and Nuclear Chemistry, 316: 179-189 (2018).

Zhang, W., Sadi, B., Rinaldo, C., Chen, J., Spencer, N., Unger, K. Evaluation of Mean Transit Time of Aerosols from the Area of Origin to the Arctic with 210Pb/210Po Daily Monitoring Data, Journal of Environmental Radioactivity, 188: 79-86 (2018).

Chauhan, V., Said, Z., Daka, J., Sadi, B., Bijlani, D., et al. Is there a role for the adverse outcome pathway framework to support radiation protection? International Journal of Radiation Biology, 95: 225-232 (2019).

Additional links

Ruth Wilkins, PhD

Expertise

Radiology, Biological Dosimetry, Cytogenetics, Cell Biology, Flow Cytometry

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